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货号： bs-2604R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2604R-PE-Cy7
- 英文名称
- Anti-IL12RB2/PE-Cy7
- 中文名称
- PE-Cy7标记的白细胞介素-12受体β2抗体
- 别 名
- Interleukin-12 receptor subunit beta-2; RP11-102M16.1; IL12 receptor beta 2; IL12R beta2; Interleukin 12 receptor beta 2; Interleukin 12 receptor beta 2 chain; RP11 102M16.1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 95kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IL-12RB2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohns disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq].
Function:
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Subcellular Location:
Membrane; Single pass type I membrane protein.
Tissue Specificity:
Isoform 2 is expressed at similar levels in both naive and activated T-cells.
Post-translational modifications:
On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.
Similarity:
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 5 fibronectin type-III domains.
Database links:Entrez Gene: 282452 Cow
Entrez Gene: 489550 Dog
Entrez Gene: 100722774 Guinea pig
Entrez Gene: 3595 Human
Entrez Gene: 16162 Mouse
Entrez Gene: 397178 Pig
Entrez Gene: 100350416 Rabbit
Entrez Gene: 171334 Rat
Entrez Gene: 100820736 Sheep
Omim: 601642 Human
SwissProt: Q99665 Human
SwissProt: P97378 Mouse
Unigene: 479347 Human
Unigene: 188337 Mouse
Unigene: 207395 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.