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货号： bs-2172R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2172R-PE-Cy7
- 英文名称
- Anti-URG4/PE-Cy7
- 中文名称
- PE-Cy7标记的上调基因4抗体（C端）
- 别 名
- FLJ20654; HBV X protein up-regulated gene 4 protein; HBV X protein upregulated gene 4 protein; HBxAg up-regulated gene 4 protein; HBxAg upregulated gene 4 protein; KIAA1507; Up-regulator of cell proliferation; Upregulated gene 4; Upregulator of cell proliferation; URGCP; URGCP_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 细胞周期蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 105kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human URG4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008]
Function:
May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.
Subcellular Location:
Cytoplasm. Nucleus. Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.
Tissue Specificity:
Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines.
Database links:Entrez Gene: 55665 Human
Omim: 610337 Human
SwissProt: Q8TCY9 Human
Unigene: 709317 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
HBx是HBV感染、复制、发病和可能致癌关键蛋白,是具有多种功能的病毒调节因子,在慢性HBV感染的病程中占有举足轻重的作用 。URG4(Upregulated gene 4)也是一个从肝癌细胞中克隆出来的可以被HBx蛋白上调的新分子，URG4过量表达在乙型肝炎感染和肝癌细胞中。