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货号： bs-2701R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2701R-PE-Cy7
- 英文名称
- Anti-Sema6A/PE-Cy7
- 中文名称
- PE-Cy7标记的Sema6A抗体
- 别 名
- semaphorin 6A; Sema Q; Sema VIA; SEMA6A-1; Semaphorin 6A-1; Semaphorin Q; Semaphorin VIA; HT018; SEM6A_HUMAN; SEMA; Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; SEMA6A 1; Sema6a; SEMA6A1; Semaphorin 6A 1; Semaphorin Q; Semaphorin VIA; Semaphorin-6A; Semaphorin-6A-1; SEMAQ; VIA.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 111kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Sema6A
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
SEMA6A belongs to a subfamily characterized by an extracellular semaphorin domain, a transmembrane domain, and a long cytoplasmic tail. Members of this class can repel sympathetic and dorsal root ganglion axons in vitro, consistent with a traditional role as guidance signals. However, the length of the cytoplasmic tail, which includes an EVL-binding site in SEMA6A and an Src-binding site in SEMA6B, suggests that these semaphorins may also function as receptors. SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection. SEMA6A directly links the Ena/VASP and the semaphorin protein families since the SEMA6A protein is capable of selective binding to the protein EVL (Ena/VASP-like protein.
Function:
Can act as repulsive axon guidance cues. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation.
Subunit:
Active as a homodimer or oligomer. Interacts with EVL.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Belongs to the semaphorin family.
Contains 1 PSI domain.
Contains 1 Sema domain.
Database links:Entrez Gene: 516019 Cow
Entrez Gene: 57556 Human
Entrez Gene: 20358 Mouse
Omim: 605885 Human
SwissProt: Q9H2E6 Human
SwissProt: O35464 Mouse
Unigene: 156967 Human
Unigene: 40909 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.