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货号： bs-2183R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2183R-PE-Cy7
- 英文名称
- Anti-Claudin 11/Oligodendrocyte Specific Protein/PE-Cy7
- 中文名称
- PE-Cy7标记的少突胶质细胞跨膜蛋白抗体
- 别 名
- Oligodendrocyte Specific Protein; Oligodendrocyte transmembrane protein; Claudin 11; claudin11; claudin-11; CLDN 11; CLDN11; Oligodendrocyte transmembrane protein; OSP; OTM.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 22kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Claudin-11
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Oligodendrocyte specific protein (OSP)is the third most abundant component of central nervous system myelin. The claudin superfamily consists of many structurally related proteins. These proteins, which include claudin 1 through 18, are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that OSP/Claudin 11 determines the permeability between layers of myelin sheaths via focal adhesion. Its expression is highly regulated during development, suggesting that it may play an important role in the growth and differentiation of oligodendrocytes and other cells outside the CNS. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.
Subunit:
Interacts with tetraspanin-3/TSPAN3.
Subcellular Location:
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the claudin family.
Database links:Entrez Gene: 508268. Cow
Entrez Gene: 5010 Human
Entrez Gene: 18417 Mouse
Entrez Gene: 84588 Rat
Omim: 601326 Human
SwissProt: Q3MHK4 Cow
SwissProt: O75508 Human
SwissProt: Q60771 Mouse
SwissProt: Q99P82 Rat
Unigene: 31595 Human
Unigene: 4425 Mouse
Unigene: 8282 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.