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货号： bs-2805R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2805R-PE-Cy7
- 英文名称
- Anti-Stanniocalcin 1/PE-Cy7
- 中文名称
- PE-Cy7标记的斯钙素抗体
- 别 名
- Stanniocalcin; STC; STC1; Stanniocalcin-1; STC-1; STC1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 神经生物学 信号转导 生长因子和激素 海洋生物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 28kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Stanniocalcin 1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5 UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq].
Function:
Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla.
Similarity:
Belongs to the stanniocalcin family.
Database links:Entrez Gene: 338078 Cow
Entrez Gene: 6781 Human
Entrez Gene: 20855 Mouse
Entrez Gene: 81801 Rat
Omim: 601185 Human
SwissProt: Q9N0T1 Cow
SwissProt: P52823 Human
SwissProt: O55183 Mouse
SwissProt: P97574 Rat
Unigene: 25590 Human
Unigene: 20911 Mouse
Unigene: 10647 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
STC1蛋白实在哺乳动物中发现的糖蛋白激素,参与机体的多种生理功能,不但可以通过肾脏和肠道系统来调节钙和磷酸盐的稳态,而且在促进脑神经元的终末分化、防止因大脑局部缺血造成脑神经元的损害、以及骨和肌肉的发育等方面也有重要作用.
近来研究发现,STC-1在人类肿瘤的发生发展中也有着重要的作用.STC-1可作为一种稳定因子促进新生血管的成熟而发挥促肿瘤增殖生长，还可通过自分泌途经与肿瘤细胞表面的趋化因子和整合素相互作用,激活一系列细胞内信号,引起多种蛋白分泌,从而溶解细胞外基质屏障,使肿瘤发生侵润和转移。