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货号： bs-23151R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-23151R-PE-Cy5.5
- 英文名称
- Anti-GSTP1/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的谷胱甘肽硫转移酶pi基因/Glutathione S Transferase pi抗体
- 别 名
- Glutathione S-Transferase pi; GST-Pi; DFN7; Gst-P1; FAEES3; Fatty Acid Ethyl Ester Synthase III; Glutathione S Transferase Pi; GST3; GSTP1; GST pi; PI; GSTP1_MOUSE.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 神经生物学 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 23kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse GSTP1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Glutathione S-transferases (GSTs) function in the metabolic detoxification of various environmental carcinogens and lipid hydroperoxides. Members of the murine GSTP (glutathione S-transferase pi) family, termed Gstp1 and Gstp2, are linked to drug resistance and are markers for many cancers. Gstp proteins modulate cell signaling by interacting with c-Jun N-terminal kinase (JNK), and may play a protective role in the development of spontaneous tumors. Gstp has been found in substantia nigra and may be associated with reactive oxygen species-induced neurological disorders such as Parkinson’s disease and may additionally protect against endothelial dysfunction induced by tobacco smoke exposure.
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subunit:
Homodimer.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the GST superfamily. Pi family.
Contains 1 GST C-terminal domain.
Contains 1 GST N-terminal domain.
Database links:Entrez Gene: 2950 Human
Entrez Gene: 14870 Mouse
Entrez Gene: 24426 Rat
Omim: 134660 Human
SwissProt: P09211 Human
SwissProt: P19157 Mouse
SwissProt: P04906 Rat
Unigene: 523836 Human
Unigene: 87063 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GST-Pi是GST家族中的一种主要的同工酶，广泛存在于全身器官中，尤以肝肾含量高，具有解毒功能。在多种肿瘤中高表达。目前认为是肿瘤细胞产生耐药的一种标记，与肿瘤的耐药（阿霉素、顺铂、氮芥、环磷酰胺和瘤可宁等）有关。该抗体主要用于细胞耐药方面的研究。