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货号： bs-16457R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16457R-PE-Cy5.5
- 英文名称
- Anti-phospho-PFKM/PFK1 (Ser775)/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的磷酸化肌肉型6磷酸果糖激酶/磷酸果糖激酶1抗体
- 别 名
- PFKM (phospho S775); PFKM (phospho Ser775); p-PFKM (Ser775); Fructose 6 Phosphate Kinase; 6 Phosphofructokinase Muscle Type; GSD7; PFKA; PFK-A; PFKP; PFKX; Phosphofructo 1 Kinase Isozyme A; Phosphofructo-1-kinase isozyme A; Phosphofructokinase 1; Phosphofructokinase M; Phosphofructokinase-M; Phosphofructokinase, muscle; Phosphofructokinase, muscle type; Phosphofructokinase, polypeptide X; Phosphohexokinase; PFKAM_HUMAN; 6-phosphofructokinase, muscle type; PFK1; PFK-1; ATP-PFK; PPP1R122.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 86kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated Synthesised phosphopeptide derived from human PFKM around the phosphorylation site of Ser775)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
Function:
Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP.
Subunit:
Homo- and heterotetramers. Muscle is M4, liver is L4, and red cell is M3L, M2L2, or ML3. Interacts (via C-terminus) with HK1 (via N-terminal spermatogenic cell-specific region)
Subcellular Location:
Cytoplasm.
Post-translational modifications:
GlcNAcylation decreases enzyme activity.
DISEASE:
Glycogen storage disease 7 (GSD7) [MIM:232800]: A metabolic disorder characterized by exercise intolerance with associated nausea and vomiting, muscle cramping, exertional myopathy and compensated hemolysis. Short bursts of intense activity are particularly difficult. Severe muscle cramps and myoglobinuria develop after vigorous exercise.
Similarity:
Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade E sub-subfamily.
Database links:Entrez Gene: 506544Cow
Entrez Gene: 403849Dog
Entrez Gene: 100034116Horse
Entrez Gene: 5213Human
Entrez Gene: 18642Mouse
Entrez Gene: 733601Pig
Entrez Gene: 100345647Rabbit
Entrez Gene: 65152Rat
Omim: 610681Human
SwissProt: Q0IIG5Cow
SwissProt: P52784Dog
SwissProt: Q867C9Horse
SwissProt: P08237Human
SwissProt: P47857Mouse
SwissProt: Q2HYU2Pig
SwissProt: P00511Rabbit
SwissProt: P47858Rat
Unigene: 75160Human
Unigene: 272582Mouse
Unigene: 11004Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.