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货号： bs-19784R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19784R-PE-Cy5.5
- 英文名称
- Anti-RECQ1/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的DNA解旋酶Q1样抗体
- 别 名
- ATP dependent DNA helicase Q1; DNA helicase Q1 like; DNA helicase RecQ like type 1; RECQ L1; RecQ protein like 1; RecQ protein like; RECQL; RECQL1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 神经生物学 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 72kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RECQ1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. Two alternatively spliced transcripts, which encode the same isoform but differ in their 5 and 3 UTRs, have been described. [provided by RefSeq, Jul 2008]
Function:
DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3-5 direction.
Subunit:
Interacts with EXO1 and MLH1.
Subcellular Location:
Nuclear
Tissue Specificity:
High expression in heart, lung, skeletal muscle and kidney, low expression in brain.
Similarity:
Belongs to the helicase family. RecQ subfamily
Contains 1 helicase ATP-binding domain
Contains 1 helicase C-terminal domain.
Database links:Entrez Gene: 5965Human
Entrez Gene: 19691Mouse
Omim: 600537Human
SwissProt: P46063Human
SwissProt: Q9Z129Mouse
Unigene: 235069Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.