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货号： bs-19646R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19646R-PE-Cy5.5
- 英文名称
- Anti-Opn1mw/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的绿视蛋白敏感CBBM抗体
- 别 名
- CBBM; CBD; COD5; Color blindness, deutan; Cone dystrophy 5 (X linked); GCP; GOP; Green cone photoreceptor pigment; Green cone pigment; Green sensitive opsin; Green-sensitive opsin; Medium wave sensitive; Medium wave sensitive opsin 1; Medium-wave-sensitive opsin 1; MGC176615; MGC177321; MGC198468; MGC198469; OPN1MW; OPN1MW1; OPN1MW2; OPSG_HUMAN; Opsin 1 (cone pigments), medium wave sensitive (color blindness, deutan); Opsin 1 (cone pigments), medium wave sensitive 2; Opsin 1 (cone pigments), medium wave sensitive; Photopigment apoprotein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 40kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Opn1mw
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009]
Function:
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
Subcellular Location:
Membrane.
Tissue Specificity:
The three color pigments are found in the cone photoreceptor cells.
Post-translational modifications:
Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.
DISEASE:
Defects in OPN1MW are the cause of partial colorblindness deutan series (CBD) [MIM:303800]; also known as deuteranopia.
Defects in OPN1MW are a cause of blue cone monochromacy (BCM) [MIM:303700]. A rare X-linked congenital stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity, pendular nystagmus, and photophobia. Patients often have myopia.
Defects in OPN1MW are a cause of cone dystrophy type 5 (COD5) [MIM:303700]. A X-linked cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs.
Similarity:
Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Database links:Entrez Gene: 2652Human
Entrez Gene: 728458Human
Entrez Gene: 14539Mouse
Entrez Gene: 89810Rat
Omim: 300821Human
Omim: 303800Human
SwissProt: P04001Human
SwissProt: O35599Mouse
SwissProt: O35476Rat
Unigene: 247787Human
Unigene: 571751Human
Unigene: 284825Mouse
Unigene: 81056Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.