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货号： bs-19251R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19251R-PE-Cy5.5
- 英文名称
- Anti-NIPAL4/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的镁转运蛋白NIPAL4抗体
- 别 名
- 9530066K23Rik; ICHN; Ichthyin; ICHYN; Magnesium transporter NIPA4; NIPA like 4; NIPA like domain containing 4; NIPA-like protein 4; NIPA4_HUMAN; NIPAL4; Non-imprinted in Prader-Willi/Angelman syndrome region protein 4; RGD1309452; RP23-29H5.5.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 50kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NIPAL4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene likely encodes a membrane receptor. Mutations in this gene have been associated with autosomal recessive congenital ichthyosis. [provided by RefSeq, Feb 2010]
Function:
Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway.
Subcellular Location:
Membrane.
Tissue Specificity:
Highly expressed in brain, lung, stomach, keratinocytes and leukocytes, and in all other tissues tested except liver, thyroid and fetal brain.
DISEASE:
Defects in NIPAL4 are the cause of ichthyosis congenital autosomal recessive ichthyin-related (ARCII) [MIM:612281]. ARCII is a disorder of keratinization with abnormal differentiation and desquamation of the epidermis. The phenotype usually presents as non-bullous congenital ichthyosiform erythroderma (NCIE) with fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. Some of the families may show a more lamellar phenotype (lamellar ichthyosis).
Similarity:
Belongs to the NIPA family.
Database links:Entrez Gene: 348938Human
Entrez Gene: 214112Mouse
Omim: 609383Human
SwissProt: Q0D2K0 Human
SwissProt: Q8BZF2Mouse
Unigene: 4285Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.