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货号： bs-17152R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17152R-PE-Cy5.5
- 英文名称
- Anti-TRIOBP/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的TRIOBP蛋白抗体
- 别 名
- DFNB28; KIAA1662; Protein TARA; TARA; TARA_HUMAN; Tara like protein; TRIO and F actin binding protein; Trio and filamentous actin binding protein; Trio associated repeat on actin.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 结合蛋白 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 261kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TRIOBP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008]
Function:
TRIOBP is a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. This trio binding protein also associates with F actin and stabilizes F actin structures.
Subunit:
Binds to TRIO and F-actin. May also interact with myosin II. Interacts with HECTD3.
Subcellular Location:
Nucleus. Cytoplasm; cytoskeleton. Note: Localized to F-actin in a periodic pattern.
Tissue Specificity:
Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues.
Post-translational modifications:
Ubiquitinated by HECTD3, leading to its degradation by the proteasome.
Isoform 1: Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.
DISEASE:
Deafness, autosomal recessive, 28 (DFNB28) [MIM:609823]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Contains 1 PH domain.
Database links:Entrez Gene: 11078Human
Entrez Gene: 511680Cow
Entrez Gene: 110253Mouse
Entrez Gene: 362956Rat
Omim: 609761Human
SwissProt: Q9H2D6Human
SwissProt: Q99KW3Mouse
Unigene: 533030Human
Unigene: 123714Mouse
Unigene: 119950Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.