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货号： bs-17047R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17047R-PE-Cy5.5
- 英文名称
- Anti-KIF21A/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的驱动蛋白家族成员21A抗体
- 别 名
- CFEOM; CFEOM1; DKFZp779C159; FEOM; FEOM1; FEOM3A; Fibrosis of extraocular muscles congenital 1 autosomal dominant; Fibrosis of the extraocular muscles congenital 1; FLJ20052; KI21A_HUMAN; KIAA1708; KIF21A; Kinesin family member 21A; kinesin like protein KIF2; kinesin like protein KIF21A; Kinesin-like protein KIF2; Kinesin-like protein KIF21A; NY-REN-62 antigen; renal carcinoma antigen NY REN 62; Renal carcinoma antigen NY-REN-62.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 187kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KIF21A
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
Function:
Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity.
Subcellular Location:
Cytoplasm >cytoskeleton.
DISEASE:
Defects in KIF21A are a cause of congenital fibrosis of extraocular muscles type 1 (CFEOM1) [MIM:135700]. CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM1 individuals show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding oculomotor subnuclei.
Similarity:
Belongs to the kinesin-like protein family.
Contains 1 kinesin-motor domain.
Contains 7 WD repeats.
Database links:Entrez Gene: 55605Human
Entrez Gene: 16564Mouse
Omim: 608283Human
SwissProt: Q7Z4S6Human
SwissProt: Q9QXL2Mouse
Unigene: 374201Human
Unigene: 41379Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.