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货号： bs-16920R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16920R-PE-Cy5.5
- 英文名称
- Anti-KCNV1/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的电压门控钾通道亚基Kv8.1抗体
- 别 名
- KCNV1; KCNV1_HUMAN; Neuronal potassium channel alpha subunit HNKA; Potassium voltage gated channel subfamily V member 1; Potassium voltage-gated channel subfamily V member 1; Voltage gated potassium channel subunit Kv8.1; Voltage-gated potassium channel subunit Kv8.1
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 通道蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 56kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KCNT1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008]
Function:
Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.
Subcellular Location:
Cell membrane. Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2.
Tissue Specificity:
Detected in brain.
Post-translational modifications:
Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity.
Similarity:
Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
Database links:Entrez Gene: 27012Human
Entrez Gene: 505732Cow
Entrez Gene: 67498Mouse
Entrez Gene: 60326Rat
Omim: 608164Human
SwissProt: Q0P583Cow
SwissProt: Q6PIU1Human
SwissProt: Q8BZN2Mouse
SwissProt: P97557Rat
Unigene: 13285Human
Unigene: 300079Mouse
Unigene: 42920Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.