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货号： bs-16628R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16628R-PE-Cy5.5
- 英文名称
- Anti-Importin 13/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的Importin 13蛋白抗体
- 别 名
- Imp 13; Imp13; Importin-13; Importin13; IPO 13; IPO13; IPO13_HUMAN; Kap 13; Kap13; Karyopherin 13; Karyopherin-13; Karyopherin13; KIAA0274; Late gestation lung 2; Late gestation lung 2 protein; Lgl2; Ran binding protein 13; Ran-binding protein 13; RanBP 13; RanBP13
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 108kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Importin 13
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]
Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Expressed in fetal brain, heart, intestine and kidney.
Similarity:
Belongs to the importin beta family.
Contains 14 HEAT repeats.
Contains 1 importin N-terminal domain.
Database links:Entrez Gene: 9670Human
Entrez Gene: 523399Cow
Entrez Gene: 230673Mouse
Entrez Gene: 116458Rat
GenBank: NM_014652Human
Omim: 610411Human
SwissProt: A7YWD2Cow
SwissProt: O94829Human
SwissProt: Q8K0C1Mouse
SwissProt: Q9JM04Rat
Unigene: 158497Human
Unigene: 287810Mouse
Unigene: 14252Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.