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货号： bs-14023R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-14023R-PE-Cy5.5
- 英文名称
- Anti-CPN1/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的激肽酶1抗体
- 别 名
- ACBP; Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N catalytic chain; Carboxypeptidase N polypeptide 1; Carboxypeptidase N polypeptide 1 50 kD; Carboxypeptidase N small subunit; CBPN_HUMAN; CPN; CPN1; Kininase 1; Kininase-1; Kininase1; Lysine carboxypeptidase; Plasma carboxypeptidase B; SCPN; Serum carboxypeptidase N.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 激酶和磷酸酶 泛素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 52kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CPN1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
Function:
Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
Subcellular Location:
Secreted > extracellular space.
Tissue Specificity:
Synthesized in the liver and secreted in plasma.
DISEASE:
Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND) [MIM:212070]. Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.
Similarity:
Belongs to the peptidase M14 family.
Database links:Entrez Gene: 1369Human
Entrez Gene: 93721Mouse
Entrez Gene: 365466Rat
Omim: 603103Human
SwissProt: Q2KJ83Cow
SwissProt: P15169Human
SwissProt: Q9JJN5Mouse
SwissProt: Q9EQV8Rat
Unigene: 2246Human
Unigene: 206774Mouse
Unigene: 145303Rat
Unigene: 162532Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.