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货号： bs-0284R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0284R-HRP
- 英文名称
- Anti-IASPP/HRP
- 中文名称
- 辣根过氧化物酶标记的肿瘤细胞凋亡ASPP家族的另一个成员抗体
- 别 名
- IASPP; inhibitor of apoptosis stimulating protein of p53; Inhibitor of ASPP protein; NFkB interacting protein 1; NKIP1; PPP1R13B-like protein; PPP1R13L;Protein iASPP; protein phosphatase 1 regulatory (inhibitor) subunit 13 like; RAI; RelA-associated inhibitor; IASPP_HUMAN; RelA-associated inhibitor; Inhibitor of ASPP protein; NFkB-interacting protein 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 染色质和核信号 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Sheep, Guinea Pig,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 89kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IASPP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
iASPP(inhibitor of apoptosis stimulating protein of p53)regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. Belongs to the ASPP family.
Function:
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.
Subunit:
Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73.
Subcellular Location:
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear.
Tissue Specificity:
Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.
Similarity:
Belongs to the ASPP family.
Contains 2 ANK repeats.
Contains 1 SH3 domain.
Database links:Entrez Gene: 10848 Human
Entrez Gene: 333654 Mouse
Omim: 607463 Human
SwissProt: Q8WUF5 Human
SwissProt: Q3TCU2 Mouse
SwissProt: Q5I1X5 Mouse
Unigene: 466937 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.IASPP(inhibitory member of the ASPP family) 是新近发现的高度保守的p53相关基因, 是细胞凋亡ASPP家族的另一个成员。
iASPP能够抑制ASPP1，2的促凋亡作用，其蛋白产物定位于细胞核内,具有结合NF-κB p65亚基和p53功能,进而抑制NF-κB的转录调节和p53对凋亡的调节功能。
研究者发现iASPP蛋白，能够干扰p53基因发挥正常的促使细胞死亡的作用。这就意味着iASPP在正常细胞转化为癌症细胞方面起着重要的促进作用，即iASPP具有促进癌变的功能。表达位置：细胞浆，部分细胞核。
inhibitor of ASPP