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货号： bs-1547R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1547R-PE-Cy5.5
- 英文名称
- Anti-Cathepsin E/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的组织蛋白酶E抗体
- 别 名
- Cathepsin E; CATE; CTSE; EC 3.4.23.34; Erythrocyte membrane aspartic proteinase; CATE_HUMAN; Cathepsin E form II; Slow moving proteinase.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 合成与降解
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 38kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Cathepsin E
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Cathepsin E is an intracellular aspartic protease of the pepsin family, which is structurally highly homologous to the lysosomal aspartic protease cathepsin D. Cathepsin E is less abundant than Cathepsin D and has a more limited distribution, which includes lymphoid tissues, gastrointestinal tract tissue, blood cells, microglia and activated B lymphocytes. It is not expressed in resting B lymphocytes. Cathepsin E may have a role in immune function. It is most likely involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. It may also play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
Function:
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
Subcellular Location:
Endosome. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
Tissue Specificity:
Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.
Post-translational modifications:
Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.
Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.
Similarity:
Belongs to the peptidase A1 family.
Database links:Entrez Gene: 1510 Human
Entrez Gene: 13034 Mouse
Entrez Gene: 25424 Rat
Omim: 116890 Human
SwissProt: P14091 Human
SwissProt: P70269 Mouse
SwissProt: P16228 Rat
Unigene: 644082 Human
Unigene: 92738 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.