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货号： bs-1844R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1844R-PE-Cy5.5
- 英文名称
- Anti-LRIG1/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的LRIG1抗体
- 别 名
- leucine-rich repeat protein LRIG1; leucine rich repeats and immunoglobulin-like domains 1; Leucine rich repeat protein; leucine rich repeats and immunoglobulin like domains 1; LIG 1; LIG-1; LRIG1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 120kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LRIG1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
LRIG1 protein is coded by a gene on a chromosome band 3p14.3, a region known to be deleted in various human cancers. It is considered to be a tumour suppressor gene. LRIG1 is an integral cell-surface membrane protein that is expressed by specific cells in various human tissues. Its 143kDa form may be cleaved into 111kDa and 32kDa fragments. The protein may inhibit the growth of tumors of glial cells and the down-regulation of the LRIG1 gene may be involved in the development and progression of the tumor.
Subunit:
Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Widely expressed.
Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 15 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain.
Database links:Entrez Gene: 26018 Human
Entrez Gene: 16206 Mouse
Omim: 608868 Human
SwissProt: Q96JA1 Human
SwissProt: P70193 Mouse
Unigene: 518055 Human
Unigene: 245210 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LRIG1属于LRIGs基因家族。LRIGs是新发现的一类基因，在哺乳动物体内广泛存在，目前发现该家族至少包括三个成员：LRIG1、LRIG2和LRIG3，是一类结构相似的跨膜糖蛋白，该蛋白人、鼠的同源性较高。
目前在肿瘤方面的研究较多，有研究认为：LRIG1是通过下调EGFR的表达来抑制其下游重要信号传导通路的激活而发挥抑癌作用，LRIG1在抑制肿瘤转移中具有重要作用。<