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货号： bs-1845R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1845R-PE-Cy5.5
- 英文名称
- Anti-LRIG2/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的LRIG2抗体
- 别 名
- DKFZp451C181; KIAA0806; LIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 precursor; LRIG2_HUMAN; UFS2; LIG-2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 117kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LRIG2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
LRIG2 is produced in all human glioma cell lines and localizes to perinuclear compartments, cytoplasmic compartments and the cell surface. It acts as a negative feedback regulator of signaling through enhanced receptor ubiquitination and accelerated intracellular degradation. LRIG2 may function as a tumour suppressor since it downregulates the expression of EGF and the related proteins ErbB-2, ErbB-3 and ErbB-4, which all inhibit cancer cells from growth, migration and invasion.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Tissue Specificity:
Detected in all tissues analyzed.
Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 15 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
Database links:Entrez Gene: 9860 Human
Omim: 608869 Human
SwissProt: O94898 Human
Unigene: 448972 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LRIG1属于LRIGs基因家族。LRIGs是新发现的一类基因，在哺乳动物体内广泛存在，目前发现该家族至少包括三个成员：LRIG1、LRIG2和LRIG3，是一类结构相似的跨膜糖蛋白，该蛋白人、鼠的同源性较高。
目前在肿瘤方面的研究较多，有研究认为：LRIG1是通过下调EGFR的表达来抑制其下游重要信号传导通路的激活而发挥抑癌作用，LRIG1在抑制肿瘤转移中具有重要作用。