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货号： bs-1849R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1849R-PE-Cy5.5
- 英文名称
- Anti-Midkine/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的中期因子/肝素结合生长因子抗体
- 别 名
- Amphiregulin associated protein; ARAP; FLJ27379; MDK; Midgestation and kidney protein; MK 1; MK; MK1; NEGF 2; NEGF2; neurite growth promoting factor 2; Neurite outgrowth promoting protein; MK_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Fruit Fly,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 13.4kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Midkine
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Midkine exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Its expression is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines.
Function:
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).
Subunit:
Homodimer. Interacts with ALK.
Subcellular Location:
Secreted.
Similarity:
Belongs to the pleiotrophin family.
Database links:Entrez Gene: 280852 Cow
Entrez Gene: 4192 Human
Entrez Gene: 17242 Mouse
Entrez Gene: 81517 Rat
Omim: 162096 Human
SwissProt: P21741 Human
SwissProt: P12025 Mouse
SwissProt: Q9R1S9 Rat
Unigene: 21528 Cow
Unigene: 82045 Human
Unigene: 906 Mouse
Unigene: 17447 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
中期因子(midkine, MK)具有多种生物学功能: 可促进神经轴突的生长和各种胚胎神经元的存活,做为一种有丝分裂原,与肿瘤的发生密切相关，MK还有较强的促血管生成特性, 经研究证实, MK可促进内皮细胞增殖并提高血管的密度，在多种肿瘤组织和肿瘤患者的血清中的水平都明显升高。MK和多向促激素(p leiotro2phin, PTN)同属于一类新的结合肝素的生长因子家族。