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货号： bs-1881R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1881R-PE-Cy5.5
- 英文名称
- Anti-Securin/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的垂体肿瘤转化基因抗体
- 别 名
- AW555095; C87862; Cut2; EAP 1; EAP1; ESP1 ASSOCIATED PROTEIN 1; Esp1-associated protein; hPTTG; MGC126883; MGC138276; Pds1; Pituitary tumor transforming 1; Pituitary tumor transforming protein 1; Pituitary tumor-transforming 1, isoform CRA_a; Pituitary tumor-transforming 1, isoform CRA_b; Pituitary tumor-transforming gene 1; Pituitary tumor-transforming gene 1 protein; PTTG 1; PTTG; PTTG1; PTTG1 protein; PTTG1_HUMAN; Pttg3; Securin; TUMOR TRANSFORMING 1; Tumor transforming protein 1; TUMOR-TRANSFORMING 1; Tumor-transforming protein 1; TUTR 1; TUTR1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 细胞周期蛋白 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 22-28kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PTTG1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The encoded protein is a homolog of yeast securing proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013].
Function:
Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer.
Subcellular Location:
Cytoplasm. Nucleus.
Post-translational modifications:
Phosphorylated at Ser-165 by CDK1 during mitosis.
Phosphorylated in vitro by ds-DNA kinase.
Ubiquitinated through Lys-11 linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. Lys-11-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10.
Similarity:
Belongs to the securin family.
Database links:Entrez Gene: 9232 Human
Entrez Gene: 30939 Mouse
Entrez Gene: 64193 Rat
Omim: 604147 Human
SwissProt: O95997 Human
SwissProt: Q6IAL9 Human
SwissProt: Q3Y5K4 Mouse
SwissProt: Q5SRU0 Mouse
SwissProt: Q9CQJ7 Mouse
SwissProt: P97613 Rat
Unigene: 350966 Human
Unigene: 6856 Mouse
Unigene: 137183 Rat
Unigene: 271 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
垂体肿瘤转化基因PTTG可在多种肿瘤组织及部分正常组织细胞内表达较高,对促进细胞增殖、转化及肿瘤发生有重要作用。