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货号： bs-1882R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-1882R-PE-Cy5.5
- 英文名称
- Anti-MRas/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的原癌基因M-ras抗体
- 别 名
- Mras; M-RAS; M ras; muscle RAS oncogene homolog precursor; Muscle and microspikes Ras; Muscle Ras oncogene homologue; R ras3; R-ras3; Ras related protein MRas; Ras related protein RRas3; RRas3; XRas.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 23kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MRAS
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MRas is a member of the RAS superfamily of GTP-binding proteins which are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors. MRas participates in reorganisation of actin cytoskeleton. It is also involved in focal adhesion and can activate MAPK signalling.
Function:
May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.
Subcellular Location:
Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).
Tissue Specificity:
Expression highly restricted to the brain and heart.
Similarity:
Belongs to the small GTPase superfamily. Ras family.
Database links:Entrez Gene: 22808 Human
Entrez Gene: 17532 Mouse
Entrez Gene: 25482 Rat
Omim: 608435 Human
SwissProt: O14807 Human
SwissProt: O08989 Mouse
SwissProt: P97538 Rat
Unigene: 527021 Human
Unigene: 2045 Mouse
Unigene: 10641 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
M-ras癌变基因的表达产物Ras蛋白存在于多数肿瘤之中，目前是肿瘤研究较重要的蛋白之一.