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货号： bs-2616R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2616R-PE-Cy5.5
- 英文名称
- Anti-IL18R Beta/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的白细胞介素-18受体β链抗体
- 别 名
- IL-18R Beta; Interleukin-18 receptor beta; Accessory protein like; IL18R Beta; AcPL; IL 18RacP; IL 1R accessor protein like; IL 1R7; IL 1RacPL; IL18Rbeta; Interleukin 18 receptor accessory protein; IL18RAP; Interleukin-18 receptor accessory protein-like; IL-18R-beta; IL-18Rbeta; Accessory protein-like; AcPL; Interleukin-1 receptor 7; IL-1R-7; IL-1R7; CD218 antigen-like family member B; CD218b; I18RA_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 68kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IL-18R beta
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
IL18R Beta is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and IL18R Beta is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18.
Function:
Required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK.
Subunit:
Together with IL18R1, probably belongs to the IL-18 receptor complex. Seems not to interact directly with IL-18.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells.
Similarity:
Belongs to the interleukin-1 receptor family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain.
Database links:Entrez Gene: 8807 Human
Entrez Gene: 16174 Mouse
Omim: 604509 Human
SwissProt: O95256 Human
SwissProt: Q9Z2B1 Mouse
Unigene: 158315 Human
Unigene: 20466 Mouse
Unigene: 392521 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.