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货号： bs-2333R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-2333R
- 英文名称
- NPRC
- 中文名称
- 利钠肽受体C抗体
- 别 名
- ANP C; ANPC; ANPRC; Atrial natriuretic peptide C type receptor; Atrionatriuretic peptide receptor C; Natriuretic peptide receptor C/guanylate cyclase C; NPR 3; NPR C; NPR3; NPRC; ANPRC_HUMAN.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 心血管 细胞生物 免疫学 细胞膜受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Horse,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 57kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NPR-C:301-400/541
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Natriuretic peptide receptor C does not exhibit guanylate cyclase activity. There seem to be at least three ANP receptors: two with guanylate cyclase activity (ANPA and ANPB) and one (ANPC) which is probably responsible for the clearance of ANP from the circulation without a role in signal transduction.
Function:
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
Subunit:
Homodimer; disulfide-linked. Dimers can also be formed through the C-terminal cysteine of isoform 2.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Belongs to the ANF receptor family.
SWISS:
P17342
Gene ID:
4883
Database links:Entrez Gene: 281358 Cow
Entrez Gene: 4883 Human
Entrez Gene: 18162 Mouse
Entrez Gene: 25339 Rat
Omim: 108962 Human
SwissProt: P10730 Cow
SwissProt: P17342 Human
SwissProt: P70180 Mouse
SwissProt: P41740 Rat
Unigene: 237028 Human
Unigene: 619466 Human
Unigene: 25259 Mouse
Unigene: 11297 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Sample:
HL-60 (Human) Cell Lysate at 40 ug
A431 (Human) Cell Lysate at 40 ug
Kidney (Mouse) Lysate at 40 ug
Primary: Anti-NPRC (bs-2333R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 57 kD
Observed band size: 57 kD
Paraformaldehyde-fixed, paraffin embedded (Human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NPRC) Polyclonal Antibody, Unconjugated (bs-2333R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.