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货号： bs-11383R-PE-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11383R-PE-Cy5.5
- 英文名称
- Anti-Acetoacetyl-CoA synthetase/PE-Cy5.5
- 中文名称
- PE-Cy5.5标记的脂肪酰辅酶A家族成员1抗体
- 别 名
- Acetoacetyl-CoA synthetase; ACSF1; AACS; Acyl-CoA synthetase family member 1; Protein sur-5 homolog; AACS_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 75kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human AACS (182-228aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
- 产品介绍
- background:
ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.
Function:
Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development
Subcellular Location:
Cytoplasm, cytosol
Tissue Specificity:
Highly expressed in kidney, heart and brain, but low in liver.
Similarity:
Belongs to the ATP-dependent AMP-binding enzyme family.
Database links:Entrez Gene: 65985Human
Entrez Gene: 78894Mouse
Entrez Gene: 65984Rat
Omim: 614364Human
SwissProt: Q86V21Human
SwissProt: Q9D2R0Mouse
SwissProt: Q9JMI1Rat
Unigene: 656073Human
Unigene: 431573Mouse
Unigene: 9215Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.