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货号： bs-23390R-PE-Cy5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-23390R-PE-Cy5
- 英文名称
- Anti-PTP4A1/PE-Cy5
- 中文名称
- PE-Cy5标记的肝再生磷酸酯酶1抗体
- 别 名
- HH 72; HH72; Hypothetical protein DKFZp779M0721; PRL 1; PRL-1; PRL1; Protein tyrosine phosphatase PTPCAAX1; Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase type IVA member 1; Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; PTP(CAAXI); PTPCAAX1; TP4A1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 信号转导 转录调节因子 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 25kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PTP4A1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
PTP4A1 belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.
Function:
Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection.
Subcellular Location:
Secreted.
Tissue Specificity:
Abundantly expressed in lacrimal gland where it found in the secretory endpieces. Also expressed at modest levels in the submandibular gland.
Similarity:
Belongs to the PROL1/PROL3 family.
Database links:Entrez Gene: 7803 Human
Entrez Gene: 100044742 Mouse
Entrez Gene: 19243 Mouse
Entrez Gene: 100360241 Rat
Entrez Gene: 100365697 Rat
Entrez Gene: 29463 Rat
Omim: 601585 Human
SwissProt: Q93096 Human
SwissProt: Q63739 Mouse
SwissProt: Q78EG7 Rat
Unigene: 227777 Human
Unigene: 480653 Mouse
Unigene: 491181 Mouse
Unigene: 121311 Rat
Unigene: 9459 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.