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货号： bs-19884R-PE-Cy5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19884R-PE-Cy5
- 英文名称
- Anti-PARP10/PE-Cy5
- 中文名称
- PE-Cy5标记的多腺苷二磷酸多聚酶PARP10抗体
- 别 名
- ADP ribosyltransferase diphtheria toxin like 10; ARTD10; PARP 10; Poly (ADP ribose) polymerase family member 10; Poly [ADP ribose] polymerase 10.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 表观遗传学 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 110kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PARP10
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
Function:
May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.
Subcellular Location:
Nucleus.Cytoplasm.
Tissue Specificity:
Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon.
Post-translational modifications:
Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells.
Similarity:
Contains 1 PARP catalytic domain.
Database links:Entrez Gene: 84875Human
Entrez Gene: 671535Mouse
Entrez Gene: 100362108Rat
Omim: 609564Human
SwissProt: Q53GL7Human
Unigene: 348609Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.