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货号： bs-19791R-PE-Cy5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19791R-PE-Cy5
- 英文名称
- Anti-Histone binding protein/SLBP/PE-Cy5
- 中文名称
- PE-Cy5标记的组蛋白结合蛋白SLBP抗体
- 别 名
- Hairpin binding protein histone; HBP; Histone binding protein; Histone RNA hairpin binding protein; Histone RNA hairpin-binding protein; Histone stem-loop-binding protein; SLBP; SLBP_HUMAN; Stem loop (histone) binding protein; stem loop binding protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 细胞周期蛋白 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Zebrafish, Firefly,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 30kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Histone binding protein/SLBP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]
Function:
RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5 side of the stem-loop structure of histone pre-mRNAs.
Subcellular Location:
Cytoplasm. Nucleus. Polyribosome-associated. Localizes predominantly in the nucleus at the G1/G2 phases and the beginning of S phase. Through the S phase, partially redistributes to the cytoplasm. Binding to histone mRNA is necessary for cytoplasmic localization. Shuttles between the nucleus and the cytoplasm. Imported in the nucleus by the Importin alpha/Importin beta receptor.
Tissue Specificity:
Widely expressed.
Post-translational modifications:
Phosphorylated on Thr-61 and Thr-62 in the S-phase. Phosphorylation of Thr-62 by CDK1 primes phosphorylation of Thr-61 by CK2. Phosphorylation of Thr-62 is required for its degradation by the proteasome at the end of the S phase. Its degradation is not required for histone mRNA degradation at the end of the S phase. All the phosphorylated forms detected are present in the cytoplasm. Both unphosphorylated and phosphorylated forms bind the stem-loop structure of histone mRNAs.
DISEASE:
Regulated during the cell cycle: protein levels increase 10 to 20 fold in the late G1 and decrease at the S/G2 border.
Similarity:
Belongs to the SLBP family.
Database links:Entrez Gene: 422902Chicken
Entrez Gene: 444868Cow
Entrez Gene: 43448 Fruit fly (Drosophila melanogaster)
Entrez Gene: 7884Human
Entrez Gene: 20492Mouse
Entrez Gene: 681062Rat
Entrez Gene: 407727Zebrafish
Omim: 602422Human
SwissProt: Q9VAN6 Fruit fly (Drosophila melanogaster)
SwissProt: Q14493Human
SwissProt: P97440Mouse
Unigene: 4801 Fruit fly (Drosophila melanogaster)
Unigene: 298345Human
Unigene: 4172Mouse
Unigene: 198386Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.