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货号： bs-19589R-PE-Cy5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19589R-PE-Cy5
- 英文名称
- Anti-PTPN12/PE-Cy5
- 中文名称
- PE-Cy5标记的酪氨酸蛋白磷酸酶非受体型12抗体
- 别 名
- Protein tyrosine phosphatase G1; Protein tyrosine phosphatase non receptor type 12; Protein-tyrosine phosphatase G1; PTN12_HUMAN; PTP PEST; PTP-PEST; PTPG1; Ptpn12; Tyrosine protein phosphatase non receptor type 12; Tyrosine-protein phosphatase non-receptor type 12.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶 细胞分化
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 88kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PTPN12
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Function:
Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2.
Subunit:
Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN (By similarity). {ECO:0000250}.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Phosphorylated by STK24/MST3 and this results in inhibition of its activity. {ECO:0000269|PubMed:17046825}.
Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.Contains 1 tyrosine-protein phosphatase domain.
Database links:Entrez Gene: 5782Human
Entrez Gene: 531877Cow
Entrez Gene: 19248Mouse
Entrez Gene: 117255Rat
Omim: 600079Human
SwissProt: Q05209Human
SwissProt: P35831Mouse
SwissProt: Q63745Rat
Unigene: 34723Cow
Unigene: 61812Human
Unigene: 319117Mouse
Unigene: 10707Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.