SB-415286
货号：
10010247-10mg 基本售价：
4116.0 元 规格：
10 mg
产品信息
概述| 货号 | 10010247-10mg |
| 描述 | Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors, and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis, and inflammation. SB-415286 is a potent and selective cell-permeable, ATP-competitive inhibitor of GSK3α with an IC50 value of 78 nM (similar potency for GSK3β) and a Ki value of 31 nM. 1 As a result of GSK3 inhibition, SB-415286 stimulates glycogen synthesis in the Chang human liver cell line with an EC50 value of 2.9 µM.1 SB-415286 also protects primary neurons from death induced by the PI3-kinase pathway.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Coghlan, M.P.,Culbert, A.A.,Cross, D.A.E., et al. Selective small molecule inhibitors or glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chemistry & Biology 7(10), 793-803 (2000).
2.Cross, D.A.E.,Culbert, A.A.,Chalmers, K.A., et al. Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death. Journal of Neurochemistry 77, 94-102 (2001).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 359.7 |
| 分子式 | C16H10ClN3O5 |
| CAS号 | 264218-23-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
