| 货号 | 316767-500ug |
| 描述 | Fluprostenol-d4 contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of fluprostenol by GC- or LC-mass spectrometry. Fluprostenol is a metabolically stable analog of prostaglandin F2α(PGF2α) with potent FP receptor agonist activity.11,2 It inhibits PGF2α binding to human and rat FP receptors with IC50 values of 3.5 and 7.5 nM, respectively.1,2 Fluprostenol is a much more potent luteolytic agent than PGF2α in rats with a minimum fully effective dose of 270 · g/kg to terminate pregnancy.3 It is also an effective inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 value of 3-10 x 10−11M.4 |
| 别名 | 16-m-trifluoromethylphenoxy tetranor Prostaglandin F2α-d4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dukes, M.,Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F2α. Nature 250, 330-331 (1974). 2.Lake, S.,Gullberg, H.,Wahlqvist, J., et al. Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor. FEBS Letters 355, 317-325 (1994). 3.Abramovitz, M.,Boie, Y.,Nguyen, T., et al. Cloning and expression of a cDNA for the human prostanoid FP receptor. The Journal of Biological Chemisty 269, 2632-2636 (1994). 4.Serrero, G., and Lepak, N.M. Prostaglandin F2α receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochemical and Biophysical Research Communications 233, 200-202 (1997). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 462.5 |
| 分子式 | C23H25D4F3O6 |
| 稳定性 | ≥ 2 years |
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