AG-041R
货号：
10010129-10mg 基本售价：
4032.0 元 规格：
10 mg
产品信息
概述| 货号 | 10010129-10mg |
| 描述 | The peptide hormone gastrin acts through G protein-coupled cholecystokinin-2 (CCKB) receptors to regulate cell proliferation, differentiation, apoptosis, and gene expression of gastrointestinal cells and exerts trophic effects on a number of gastric cancer cell lines. AG-041R is a potent gastrin/cholecystokinin-2 (CCKB) receptor antagonist that exhibits selective binding for CCKB compared to CCKA.1 AG-041R inhibits gastrin-evoked secretion of pancreastatin (IC50 = 2.2 nM) as well as gastrin-induced histamine release and cell growth of Mastomys ECL carcinoid tumor cells.1,2 AG-041R (1 µM) exhibits synergistic inhibitory effects on the cell viability of human gastric cancer cells when administered in combination with the selective COX-2 inhibitor NS-398 (Item No. 70590) at 10 µM.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chiba, T.,Kinoshita, Y.,Sawada, M., et al. The role of endogenous gastrin in the development of enterochromaffin-like cell carcinoid tumors in Mastomys natalensis: A study with the specific gastrin receptor antagonist AG-041R. Yale Journal of Biology and Medicine 71, 247-255 (1998).
2.Lindström, E.,Björkqvist, M., and Håkanson, R. Pharmacological analysis of CCK2 receptor antagonists using isolated rat stomach ECL cells. British Journal of Pharmacology 127, 530-536 (1999).
3.Sun, W.H.,Zhu, F.,Chen, G.S., et al. Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro. Cancer Letters 263, 302-311 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 544.7 |
| 分子式 | C31H36N4O5 |
| CAS号 | 159883-95-1 |
| 稳定性 | ≥ 2 years |
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