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货号: bs-2622R 基本售价: 1380.0 元 规格: 100ul
- 规格:100ul
- 价格:1380.00元
- 规格:200ul
- 价格:2200.00元
产品信息
- 产品编号
- bs-2622R
- 英文名称
- IL21R
- 中文名称
- 白介素21受体抗体
- 别 名
- IL 21R; IL-21R; IL21 Receptor; IL21R; Interleukin 21 receptor; MGC10967; NILR; IL21R_HUMAN; CD360; IL-21 receptor; IL21 Receptor; Interleukin-21 receptor; Novel interleukin receptor.
- Specific References (1) | bs-2622R has been referenced in 1 publications.[IF=3.06] Guan, Li-juan, et al. "Increased IL-21/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease." Cytokine 72.2 (2015): 160-165. IHC-P ; Human.PubMed:25647271
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 免疫学 细胞膜受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 57kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IL-21R:441-538/538
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Function:
This is a receptor for interleukin-21.
Subunit:
Heterodimer with the common gamma subunit. Associates with JAK1.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Selectively expressed in lymphoid tissues. Most highly expressed in thymus and spleen.
Post-translational modifications:
C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.
Similarity:
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Contains 2 fibronectin type-III domains.
SWISS:
Q9HBE5
Gene ID:
50615
Database links:Entrez Gene: 50615 Human
Entrez Gene: 60504 Mouse
Entrez Gene: 308977 Rat
Omim: 605383 Human
SwissProt: Q9HBE5 Human
SwissProt: Q9JHX3 Mouse
SwissProt: Q5EBB1 Rat
Unigene: 210546 Human
Unigene: 155643 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
- Sample:
Thymus (Mouse) Lysate at 40 ug
Primary: Anti- IL21R (bs-2622R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kD
Observed band size: 55 kDSample:
Lymph node (Mouse) Lysate at 40 ug
Primary: Anti- IL21R (bs-2622R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kD
Observed band size: 55 kD