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货号： bs-2584R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-2584R
- 英文名称
- IGSF8
- 中文名称
- 免疫球蛋超家族成员8抗体
- 别 名
- CD316; CD316 antigen; CD81 partner 3; CD81P3; EWI-2; EWI2; Glu-Trp-Ile EWI motif-containing protein 2; igsf-8; IgSF8; IGSF8_MOUSE; Immunoglobulin superfamily member 8; Immunoglobulin superfamily member 8 precursor; KCT-4; KCT4; Keratinocytes-associated transmembrane protein 4; LIR-D1; PGRL; Prostaglandin regulatory-like protein.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 免疫学 微生物学 细菌及病毒
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 62kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse IGSF8:101-200/611 <Extracellular>
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
IGSF8 is a 65kDa single-pass membrane protein that may play a key role in many of the functions attributed to CD81 and CD9, like Hepatitis C infection and oocyte fertilization. It is also believed that this protein acts as a negative regulator of cell motility (e.g. T-cell mobility, prostate cancer cell migration) and is involved in the regulation of neurite outgrowth and maintenance of the neural network in the brain.
Function:
May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
Subunit:
Interacts directly with CD82 and CD9/tetraspanin-29. Also interacts with integrin alpha-3/beta-1 and integrin alpha-4/beta-1. Interacts with CD81/tetraspanin-28.
Subcellular Location:
Cell membrane; Single-pass membrane protein.
Tissue Specificity:
Expressed in lymphocytes as well as in many tissues with higher expression in brain. Detected in all regions of the brain with weak expression in the pituitary. Expressed selectively by neurons but not by glial cells.
Similarity:
Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
SWISS:
Q8R366
Gene ID:
140559
Database links:Entrez Gene: 93185 Human
Entrez Gene: 140559 Mouse
Omim: 606644 Human
SwissProt: Q969P0 Human
SwissProt: Q8R366 Mouse
Unigene: 332012 Human
Unigene: 271717 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Sample: Brain(Mouse) lysate at 30ug;
Primary: Anti-IGSF8 (bs-2584R) at 1:300 dilution;
Secondary: HRP conjugated Goat-Anti-rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution ;
Predicted band size: 62 kD
Observed band size: 55 kD
Blank control(blue):Raji (fixed with 2% paraformaldehyde (10 min)).
Primary Antibody:Rabbit Anti-IGSF8 antibody(bs-2584R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange), used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.