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货号： bs-11539R-PE-Cy5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11539R-PE-Cy5
- 英文名称
- Anti-Alpha chimerin/PE-Cy5
- 中文名称
- PE-Cy5标记的α1-chimaerin蛋白抗体
- 别 名
- CHN 1; A-chimaerin; Alpha-chimerin; Alpha chimerin; ARHGAP2; CHIN_HUMAN; CHN; Chn1; N chimaerin; N chimerin; N-chimaerin; N-chimerin; NC; Rho GTPase-activating protein 2; RHOGAP2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 信号转导 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Alpha-chimerin (151-250aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
- 产品介绍
- background:
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duanes retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Function:
GTPase-activating protein for p21-rac and a phorbol ester receptor. May play an important role in neuronal signal-transduction mechanisms.
Subunit:
Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation
Tissue Specificity:
In neurons in brain regions that are involved in learning and memory processes.
DISEASE:
Defects in CHN1 are the cause of Duane retraction syndrome type 2 (DURS2) [MIM:604356]. Duane retraction syndrome is a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction, or both, and narrowing of the palpebral fissure and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision.
Similarity:
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Rho-GAP domain.
Contains 1 SH2 domain.
Database links:Entrez Gene: 1123Human
Entrez Gene: 108699Mouse
Entrez Gene: 84030Rat
Omim: 118423Human
SwissProt: P15882Human
SwissProt: Q91V57Mouse
SwissProt: P30337Rat
Unigene: 380138Human
Unigene: 475464Mouse
Unigene: 11166Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.