| 货号 | 74437T |
| 目标/特异性 | Each antibody in the Fanconi Anemia Antibody Sampler kit detects endogenous levels of its target protein. |
| 供应商 | CST |
| 背景 | Fanconi anemia (FA) is an autosomal recessive genetic disorder resulting in symptoms that include chromosomal breakage, bone marrow failure, hypersensitivity to DNA cross-linking agents (such as mitomycin C), and a predisposition to cancer (1). In response to DNA damage, the FA nuclear complex (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCM) induces mono-ubiquitination of FANCD2 and FANCI (2). Monoubiquitination of FANCD2 induces localization of FANCD2 to sites of DNA damage, where it interacts with BRCA1 (4). FANCJ/BRIP1, FANCD1/BRCA2, and FANCN/PALB2 are also recruited to sites of DNA damage. FA signaling is important in maintenance of chromosome stability and control of mitosis (3). |
| 存放说明 | Upon receipt of the kit, components must immediately be placed at their appropriate storage temperature in an upright position: Ambient,? 癈 to 8癈, -30 ?to 10 癈, and -85 ?to -75 癈. |
| 参考文献 | 1 . Alter, B.P. (1996) Am J Hematol 53, 99-110. 2 . Fei, P. et al. (2005) Cell Cycle 4, 80-6. 3 . Nalepa, G. and Clapp, D.W. (2014) F1000Prime Rep 6, 23. 4 . Garcia-Higuera, I. et al. (2001) Mol Cell 7, 249-62. |
