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货号： bs-20140R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20140R-PE-Cy3
- 英文名称
- Anti-GRIP2/PE-Cy3
- 中文名称
- PE-Cy3标记的谷氨酸受体相互作用蛋白2抗体
- 别 名
- Glutamate receptor-interacting protein 2; GRIP-2; GRIP2_HUMAN; GRIP2; KIAA1719.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 112kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from rat GRIP2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neuro-degeneration. The glutamate receptor interacting proteins, GRIP1 and GRIP2, are members of the PDZ domain-containing protein family, and they specifically bind to the carboxy-terminus of AMPA receptor subunits, GluR-2 and GluR-3. GRIP1 and GRIP2 are involved in the targeting of GluR-2 and GluR-3 to the synapse. GRIP1 and GRIP2 are widely expressed in brain, with the highest levels in the cerebral cortex, hippocampus and olfactory bulb. They are both enriched in synaptic plasma and postsynaptic density fractions. GRIP1 is expressed in early development before the expression of AMPA receptors, specifically postnatal days 8-10, while GRIP2 expression parallels that of AMPA receptors during later developmental stages. GRIP1 and GRIP2 may mediate the endocytotic rate of GluR-2 and GluR-3 in response to the phosphorylation of the receptors on Ser 880 by PKC, which is implicated in the induction of cerebellar long-term depression (LTD).
Function:
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.
Subunit:
Interacts with EFNB1, EFNB3, GRIA2, GRIA3, CSPG4 and GRIPAP1. Can form homomultimers and heteromultimers with GRIP1 (By similarity). Interacts with the C-terminal tail of PRLHR.
Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein.
Similarity:
Belongs to the GRIP2 family.
Contains 7 PDZ (DHR) domains.
Database links:Entrez Gene: 80852Human
Entrez Gene: 509537Cow
Entrez Gene: 484638Dog
Entrez Gene: 243547Mouse
Entrez Gene: 171571Rat
SwissProt: Q9C0E4Human
SwissProt: Q9WTW1Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.