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货号： bs-12787R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12787R-PE-Cy3
- 英文名称
- Anti-WAC/PE-Cy3
- 中文名称
- PE-Cy3标记的WAC蛋白抗体
- 别 名
- 1110067P07Rik; BA48B24; BA48B24.1; BM 016; FLJ31290; KIAA1844; MGC10753; OTTHUMP00000019380; OTTHUMP00000019382; PRO1741; wac; WAC_HUMAN; WW domain containing adapter protein with coiled coil; WW domain containing adaptor with coiled coil; WW domain-containing adapter protein with coiled-coil; Wwp4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 71kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human WAC
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Function:
Acts as a linker between gene transcription and histone H2B monoubiquitination at Lys-120 (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage.
Subcellular Location:
Nucleus speckle. Nucleus. In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes.
Post-translational modifications:
Phosphorylated on tyrosine residues.
Similarity:
Contains 1 WW domain.
Database links:Entrez Gene: 51322Human
Entrez Gene: 225131Mouse
Omim: 615049Human
SwissProt: Q9BTA9Human
SwissProt: Q924H7Mouse
Unigene: 435610Human
Unigene: 204524Mouse
Unigene: 482081Mouse
Unigene: 491095Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.