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货号： bs-17872R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17872R-PE-Cy3
- 英文名称
- Anti-MTF2/PE-Cy3
- 中文名称
- PE-Cy3标记的金属调节转录因子2抗体
- 别 名
- DJ976O13.2; hPCl2; M96; metal regulatory transcription factor 2; Metal response element binding transcription factor 2; metal-response element DNA-binding protein M96; PCL2; MTF2_HUMAN; polycomb-like 2; polycomb-like protein 2; Putative DNA binding protein; RP5 976O13.1; RP5-976O13.1; TDRD19A; tudor domain containing 19A.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 67kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MTF2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Binds to the metal-regulating-element (MRE) of metallothionein gene promoter. May be involved in the activation of MT (metallothionein) genes in response to heavy-metal ions.
Function:
Polycomb group (PcG) that specifically binds histone H3 trimethylated at Lys-36 (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).
Subunit:
Associated component of the PRC2 complex (By similarity).
Subcellular Location:
Nuclear
Similarity:
Belongs to the Polycomblike family.
Contains 2 PHD-type zinc fingers.
Contains 1 Tudor domain.
Database links:Entrez Gene: 22823Human
Entrez Gene: 17765Mouse
Entrez Gene: 360905Rat
Omim: 609882Human
SwissProt: Q9Y483Human
SwissProt: Q02395Mouse
Unigene: 229278Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.