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货号： bs-17755R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17755R-PE-Cy3
- 英文名称
- Anti-MRFAP1L1/PE-Cy3
- 中文名称
- PE-Cy3标记的T淋巴细胞活化蛋白样蛋白MRFAP1L1抗体
- 别 名
- MORF4 family-associated protein 1-like 1; MR1L1_HUMAN; MRFAP1L1; PP784.RBP1_HUMAN
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 15kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MRFAP1L1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The members of the mortality factor family include mortality factor 4 (MORF4), MORF4L1 (also known as MRG15) and MORF4-related gene X (MRGX). The human MORF4 gene maps to chromosome 4q33-q34.1. MORF4 induces a senescent-like phenotype in complementation group B immortal cell lines. MORF4 family-associated protein 1 (MRFAP1), also known as GAM14 or PGR1, is a 127 amino acid member of the MORF4 family-associated protein family. Localized to nucleus and cytoplasm, MRFAP1 colocalizes with MORF4L1 to the cell nuclei. Its association with MORF4L1 and Rb1 suggests that MRFAP1 may play a role in transcription regulation. The gene encoding human MRFAP1 maps to chromosome 4p16.1.
Function:
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX)and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
Subunit:
Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.
Subcellular Location:
Membrane
Tissue Specificity:
Expressed ubiquitously but at low levels.Shows a strong expression in the erythrocytes.
Similarity:
Belongs to the MORF4 family-associated protein family.
Database links:Entrez Gene: 114932Human
SwissProt: Q96HT8Human
Unigene: 593159Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.