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货号： bs-17739R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17739R-PE-Cy3
- 英文名称
- Anti-MPPE1/PE-Cy3
- 中文名称
- PE-Cy3标记的金属磷酸酯酶1抗体
- 别 名
- Metallo phosphoesterase; Metallophosphoesterase 1; PGAP5; Post-GPI attachment to proteins factor 5
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 45kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MPPE1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Metallophosphoesterases (MPPEs) are dynamic enzymes that catalyze a variety of cellular reactions and contain a conserved beta-alpha-beta-alpha-beta fold. The MPPE superfamily is divided into two subfamilies: phosphomonoesterases and phosphodiesterases. Each MPPE has a dimetal center located approximately at the C-terminal end of the parallel ∫-strands of the fold. MPPE1 (Metallophosphoesterase 1) is a 396 amino acid multipass membrane enzyme that requires two divalent metals as cofactors. MPPE1 contains a N-terminal signal peptide, a typical metallophosphoesterase domain and a C-terminal transmembrane domain. Expression of MPPE1 seems to be limited to brain. There are five isoforms of MPPE1 that are produced as a result of alternative splicing events.
Function:
The specific function of metallophosphoesterase 1 (MPPE1) is not yet known. There are 5 isoforms produced by alternative splicing which have molecular weights of 45 kDa, 39 kDa (2 isoforms), 38 kDa and 29 kDa.
Subunit:
Interacts with GPI-anchor proteins. Interacts with TMED10.
Subcellular Location:
Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Note: Also localizes to endoplasmic reticulum exit site.
Tissue Specificity:
Expressed in brain.
Similarity:
Belongs to the metallophosphoesterase superfamily. MPPE1 family.
Database links:Entrez Gene: 65258Human
Entrez Gene: 225651Mouse
Entrez Gene: 361344Rat
Omim: 611900Human
SwissProt: Q53F39Human
SwissProt: Q80XL7Mouse
SwissProt: B1WC86Rat
Unigene: 712666Human
Unigene: 235792Mouse
Unigene: 64185Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.