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货号： bs-5499R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5499R-HRP
- 英文名称
- Anti-phospho-MyoD1(Ser200)/HRP
- 中文名称
- 辣根过氧化物酶标记的磷酸化肌原调节蛋白抗体
- 别 名
- MyoD1 (phospho S200); p-MyoD1 (phospho S200); MYOD1(phospho S200);Myogenic differentiation 1; AI503393; bHLHc1; MD1; MGC156574; MYF3; MYOD; MYOD1; PUM; MYOD1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 34kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated Synthesised phosphopeptide derived from human MyoD1 around the phosphorylation site of Ser200
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MyoD1 belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. Myod1 is essential for repair of damaged tissue. It activates its own transcription which may stabilize commitment to myogenesis.
Function:
Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).
Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1 and CDK9. Interacts with DDX5 (By similarity).
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation.
Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).
Ubiquitinated on the N-terminus; which is required for proteasomal degradation.
Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.
Database links:Entrez Gene: 374048 Chicken
Entrez Gene: 281938 Cow
Entrez Gene: 4654 Human
Entrez Gene: 17927 Mouse
Entrez Gene: 407604 Pig
Entrez Gene: 337868 Rat
Entrez Gene: 443405 Sheep
Omim: 159970 Human
SwissProt: P16075 Chicken
SwissProt: Q7YS82 Cow
SwissProt: P15172 Human
SwissProt: P10085 Mouse
SwissProt: P49811 Pig
SwissProt: Q02346 Rat
SwissProt: P29331 Sheep
Unigene: 181768 Human
Unigene: 1526 Mouse
Unigene: 9493 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.