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货号： bs-5922R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5922R-HRP
- 英文名称
- Anti-PGRMC/HRP
- 中文名称
- 辣根过氧化物酶标记的孕激素受体膜相关元件抗体
- 别 名
- HPR6.6; Membrane associated progesterone receptor component 1; y mPR; PGRMC1; PGRMC 1; PGRMC-1; Progesterone receptor membrane component 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 免疫学 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit,
- 产品应用
- ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 21kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PGRMC (75-120aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
PGRMC1 is a progesterone receptor component of 195 aa with a 26 residue N terminal hydrophobic region and no N terminal glycosylation site. It has an overall homology of 50% with PGRMC2 but their C terminal regions have a 68% homology, including a highly conserved 58 residue sequence.PGRMC1 is a heme bind proteins that is up-regulated in several cancers. In breast tumors, PGRMC1 is associated with hypoxia estrogen receptor-negative status. PGRMC1 is also shown to stimulate AKT phosphorylation and is known to stabilise the EGFR receptor tyrosine kinase.
Function:
Receptor for progesterone (By similarity).
Subcellular Location:
Microsome membrane; Single-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass membrane protein (By similarity).
Tissue Specificity:
Widely expressed, with highest expression in liver and kidney.
Similarity:
Belongs to the cytochrome b5 family. MAPR subfamily.
Contains 1 cytochrome b5 heme-binding domain.
Database links:Entrez Gene: 317706 Cow
Entrez Gene: 10857 Human
Entrez Gene: 53328 Mouse
Entrez Gene: 396946 Pig
Entrez Gene: 291948 Rat
Omim: 300435 Human
SwissProt: Q17QC0 Cow
SwissProt: O00264 Human
SwissProt: O55022 Mouse
SwissProt: Q95250 Pig
SwissProt: P70580 Rat
Unigene: 90061 Human
Unigene: 9052 Mouse
Unigene: 102356 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.