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货号： bs-5714R-HRP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5714R-HRP
- 英文名称
- Anti-OVCA1/HRP
- 中文名称
- 辣根过氧化物酶标记的卵巢癌相关基因1抗体
- 别 名
- Candidate tumor suppressor in ovarian cancer 1; Diphthamide biosynthesis protein 1; Diphthamide biosynthesis protein 2 homolog like 1; Diphthamide biosynthesis protein 2 like; Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces) like 1 ; Diptheria toxin resistance protein required for diphthamide biosynthesis like 1; DPH like 1 (S. cerevisiae); DPH like 1; DPH1; DPH1 homolog (S. cerevisiae); DPH1 homolog; DPH2 like 1; DPH2L; DPH2L1; HsDph1; Ovarian cancer associated gene 1; Ovarian cancer associated gene 1 protein; Ovarian tumor suppressor candidate 1; DPH1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 细胞周期蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
- 产品应用
- WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 49kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human OVCA1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
OVCA1 is required for the first step in the synthesis of diphthamide, a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. OVCA1 is one of several enzymes involved in synthesis of diphthamide in EEF2.
Function:
Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity).
Subunit:
Interacts with DPH2 (By similarity). Interacts with RBM8A.
Subcellular Location:
Nucleus. Cytoplasm. Note=Punctate, primarily perinuclear localization.
Tissue Specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, mammary gland, colon, small intestine, testis and ovary. Reduced expression in primary breast and ovarian tumors.
Similarity:
Belongs to the DPH1/DPH2 family. DPH1 subfamily.
Database links:Entrez Gene: 1801 Human
Entrez Gene: 116905 Mouse
Entrez Gene: 287523 Rat
Omim: 603527 Human
SwissProt: Q9BZG8 Human
SwissProt: Q5NCQ5 Mouse
Unigene: 513856 Human
Unigene: 41496 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.