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货号： bs-7694R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7694R-PE-Cy3
- 英文名称
- Anti-SLC12A3/PE-Cy3
- 中文名称
- PE-Cy3标记的钠氯离子转运蛋白抗体
- 别 名
- Na Cl symporter;Na-Cl symporter;NaCl electroneutral thiazide sensitive cotransporter;NCCT;S12A3_HUMAN;slc12a3;Solute carrier family 12 (sodium/chloride transporters) member 3;Solute carrier family 12 member 3;Thiazide sensitive Na Cl cotransporter;Thiazide sensitive sodium chloride cotransporter;Thiazide-sensitive sodium-chloride cotransporter;TSC.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 细胞生物 通道蛋白 转运蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 113kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SLC12A3/NCCT
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Na-K-Cl cotransporters (NKCC) are channel proteins that aid in the transcellular movement of chloride across both secretory and absorptive epithelia. NKCC1 is expressed in muscle cells, neurons, and red blood cells. In the basolateral membrane of secretory epithelia, NKCC1 mediates active chloride secretion. The gene encoding human NKCC1 maps to chromosome 5q23.3. In mice, disruption of the NKCC1 gene leads to deafness and impaired balance. NKCC2 is specifically expressed in the kidney where it mediates active reabsorption of sodium chloride in the thick ascending limb of the loop of Henle. NKCC2 is sensitive to the clinically important diuretics furosemide and bumetanide. The gene encoding human NKCC2 maps to chromosome 15q15-q21 and mutations in this gene lead to Bartter’s syndrome, an inherited hypokalaemic alkalosis. NCCT is a thiazide-sensitive Na-Cl cotransporter that is primarily expressed in the distal convoluted tubule of the kidney where it accounts for a significant fraction of net renal sodium reabsorption. The gene for human NCCT map to chromosome 16q13. Mutations in the gene encoding NCCT cause Gitelman’s syndrome, a subset of Bartter’s syndrome.
Function:
Electrically silent transporter system. Mediates sodium and chloride reabsorption.
Subunit:
Interacts with KLHL3.
Subcellular Location:
Membrane.
Tissue Specificity:
Predominant in kidney.
Post-translational modifications:
Ubiquitinated; ubiquitination is essential for regulation of endocytosis (By similarity). May be ubiquitinated by the BCR(KLHL3) complex.
DISEASE:
Defects in SLC12A3 are the cause of Gitelman syndrome (GS). GS is an autosomal recessive disorder characterized by hypokalemic alkalosis in combination with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. Patients are often asymptomatic or present transient periods of muscular weakness and tetany, usually accompanied by abdominal pain, vomiting and fever. The phenotype is highly heterogeneous in terms of age at onset and severity. Cardinal features such as hypocalciuria and hypomagnesemia might also change during the life cycle of a given patient. GS has overlapping features with Bartter syndrome.
Similarity:
Belongs to the SLC12A transporter family.
Database links:Entrez Gene: 6559Human
Entrez Gene: 20497Mouse
Entrez Gene: 54300Rat
Omim: 600968Human
SwissProt: P55017Human
SwissProt: P59158Mouse
SwissProt: P55018Rat
Unigene: 669115Human
Unigene: 25804Mouse
Unigene: 10467Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.