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货号： bs-7697R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7697R-PE-Cy3
- 英文名称
- Anti-BS69/PE-Cy3
- 中文名称
- PE-Cy3标记的腺病毒5结合蛋白BS69/骨形态发生蛋白受体相关分子1抗体
- 别 名
- Adenovirus 5 E1A binding protein; Bone morphogenetic protein receptor associated molecule 1; BRAM1; BS69 variant 1; BS69 variant 2; BS69 variant 3; BS69 variant 4; Zinc finger MYND domain containing 11; ZMYND11.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 细胞周期蛋白 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Horse, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 71kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Adenovirus 5 E1A binding protein (535-584aa)
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Function:
Corepressor of transcription (Probable). May be involved in chromatin remodeling through association with several remodeling factors.
Subunit:
Interacts (via MYND-type zinc finger) with NCOR1. Interacts (via MYND-type zinc finger) with human adenovirus early E1A protein (via PXLXP motif); this interaction inhibits E1A mediated transactivation. Interacts (via MYND-type zinc finger) with Epstein-Barr virus EBNA2 protein (via PXLXP motif). Interacts (via MYND-type zinc finger) with EZH2. Interacts with E2F6.
Subcellular Location:
Nucleus. Chromosome. Note=Associates with chromatin and mitotic chromosomes.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Ubiquitinated, leading to proteasomal degradation.
Similarity:
Contains 1 bromo domain.
Contains 1 MYND-type zinc finger.
Contains 1 PHD-type zinc finger.
Contains 1 PWWP domain.
Database links:Entrez Gene: 10771 Human
Entrez Gene: 66505 Mouse
Entrez Gene: 291259 Rat
GenBank: NP_006615 Human
GenBank: NP_997644 Human
Omim: 608668 Human
SwissProt: Q15326 Human
SwissProt: Q8R5C8 Mouse
Unigene: 292265 Human
Unigene: 397307 Mouse
Unigene: 38301 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.