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货号： bs-6388R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-6388R-PE-Cy3
- 英文名称
- Anti-MDM2BP/PE-Cy3
- 中文名称
- PE-Cy3标记的双微体2癌基因结合蛋白抗体
- 别 名
- MDM 2 binding protein; MDM 2 BP; MDM2 (mouse double minute 2) binding protein 104kD; MDM2 (mouse double minute 2) binding protein; MDM2 binding protein; MDM2 BP; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein; MDM2BP; Mouse double minute 2 homolog binding protein; MTBP_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 染色质和核信号 细胞周期蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 102kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MTBP/MDM2BP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation.
Function:
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
Subunit:
Interacts with MDM2.
Similarity:
Belongs to the MTBP family.
Database links:Entrez Gene: 27085Human
Entrez Gene: 105837Mouse
Omim: 605927Human
SwissProt: Q96DY7Human
SwissProt: Q80VU3Mouse
SwissProt: Q8BJS8Mouse
SwissProt: Q8BTU9Mouse
SwissProt: Q8BTW0Mouse
SwissProt: Q9ER61Mouse
Unigene: 186433Human
Unigene: 46701Human
Unigene: 61901Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.