产品中心
当前位置：首页>产品中心Anti-NEK1/PE-Cy3
货号： bs-7814R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7814R-PE-Cy3
- 英文名称
- Anti-NEK1/PE-Cy3
- 中文名称
- PE-Cy3标记的丝氨酸/苏氨酸蛋白激酶NEK1抗体
- 别 名
- NEK1; NEK1_HUMAN; Never in mitosis A-related kinase 1; NIMA (never in mitosis gene a)-related kinase 1; NIMA-related kinase 1; NimA-related protein kinase 1; NY-REN-55; Renal carcinoma antigen NY-REN-55; Serine/threonine-protein kinase Nek1; SRPS2; DKFZp686D06121; DKFZp686K12169; KIAA1901; MGC138800.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 143kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NEK1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a serine/threoninekinase involved in cell cycle regulation. The encoded protein isfound in a centrosomal complex with FEZ1, a neuronal protein thatplays a role in axonal development. Defects in this gene are acause of polycystic kidney disease (PKD). Several transcriptvariants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2010].
Function:
Phosphorylates serines and threonines, but also appearsto possess tyrosine kinase activity. Implicated in the control ofmeiosis (By similarity). Involved in cilium assembly.
Subunit:
Binds to SPERT (By similarity).
Subcellular Location:
Nucleus (Probable). Cytoplasm, cytoskeleton,centrosome (By similarity). Note=Associated with the pericentriolarmaterial. Localizes to centrosome during interphase and mitosis (Bysimilarity).
Tissue Specificity:
High fetal expression in the brain and kidney.
DISEASE:
Defects in NEK1 are the cause of short rib-polydactylysyndrome type 2 (SRPS2) [MIM:263520]. A lethal skeletal dysplasiacharacterized by markedly short ribs, short limbs, polydactyly, andmultiple anomalies including a narrow thorax with hypoplasticlungs, extreme polysyndactyly, dysproportionate dwarfism, mediancleft lip and palate, a ventriculoseptal defect and cystic kidneys.The radiographic hallmarks include shortened and horizontal ribs,squared scapulae and elevated clavicles with lateral kinking,normal spine and pelvis configuration, and shortening of the bonesof all four extremities, with extreme reduction of tibial bonelength.
Similarity:
Belongs to the protein kinase superfamily. NEK Ser/Thrprotein kinase family. NIMA subfamily.
Contains 1 protein kinase domain.
Database links:Entrez Gene: 4750 Human
Entrez Gene: 18004 Mouse
Omim: 604588 Human
SwissProt: Q96PY6 Human
SwissProt: P51954 Mouse
Unigene: 481181 Human
Unigene: 486881 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.