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货号： bs-9228R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9228R-PE-Cy3
- 英文名称
- Anti-RNF149/PE-Cy3
- 中文名称
- PE-Cy3标记的环指蛋白149抗体
- 别 名
- DNA polymerase-transactivated protein 2; E3 ubiquitin-protein ligase RNF149; RING finger protein 149; RN149_HUMAN; Rnf149.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 40kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RNF149
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
- 产品介绍
- background:
The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF149 (RING finger protein 149), also known as DNAPTP2 (DNA polymerase-transactivated protein 2) or E3 ubiquitin-protein ligase RNF149, is a 400 amino acid single-pass membrane protein that contains one PA (protease associated) domain and a single RING-type zinc finger. The gene encoding RNF149 maps to human chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome.
Function:
E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
Subcellular Location:
Membrane.
Similarity:
Contains 1 PA (protease associated) domain.
Contains 1 RING-type zinc finger.
Database links:Entrez Gene: 284996 Human
Entrez Gene: 67702 Mouse
Entrez Gene: 363222 Rat
SwissProt: Q8NC42 Human
SwissProt: Q3U2C5 Mouse
Unigene: 142074 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.