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货号： bs-9547R-PE-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9547R-PE-Cy3
- 英文名称
- Anti-PGGT1A/PE-Cy3
- 中文名称
- PE-Cy3标记的蛋白香叶烯基转移酶1α抗体
- 别 名
- CAAX farnesyltransferase alpha subunit; Farnesyl protein transferase alpha subunit; Farnesyltransferase CAAX box alpha; Farnesyltransferase, CAAX box, alpha; FPTA; FTase alpha; GGTase I alpha; PGGT1A; Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit; Protein prenyltransferase alpha subunit repeat containing 2; PTAR2; Ras proteins prenyltransferase alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl geranyltransferase alpha subunit; FNTA_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 44kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PGGT1A/FNTA
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
FNTA, also known as CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This type of posttranslational modification provides a mechanism for membrane localization of proteins that lack a transmembrane domain. This enzyme has the remarkable property of farnesylating peptides as short as four residues in length that conform to the CAAX consensus sequence. FNTA is also a specific cytoplasmic interactor of the transforming growth factor-beta and activin type I receptors. It is likely to be a key component of the signaling pathway which involves p21ras, an important substrate for farnesyltransferase.
Function:
Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity).
Subunit:
Heterodimer of an alpha and a beta subunit. Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity).
Subcellular Location:
Cytoplasmic
Post-translational modifications:
Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity).
Similarity:
Belongs to the protein prenyltransferase subunit alpha family.
Contains 5 PFTA repeats.
Database links:Entrez Gene: 2339 Human
Entrez Gene: 14272 Mouse
Entrez Gene: 25318 Rat
Omim: 134635 Human
SwissProt: P49354 Human
SwissProt: Q61239 Mouse
SwissProt: Q04631 Rat
Unigene: 370312 Human
Unigene: 3496 Mouse
Unigene: 5990 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.